- Title
- Neutrophil lymphocyte ratio and cardiovascular disease risk: a systematic review and meta-analysis
- Creator
- Angkananard, Teeranan; Anothaisintawee, Thunyarat; McEvoy, Mark; Attia, John; Thakkinstian, Ammarin
- Relation
- BioMed Research International
- Publisher Link
- http://dx.doi.org/10.1155/2018/2703518
- Publisher
- Hindawi Publishing Corporation
- Resource Type
- journal article
- Date
- 2018
- Description
- Objective: This systematic review aimed to measure the association between neutrophil lymphocyte ratio (NLR) and cardiovascular disease (CVD) risk. Methods: Relevant studies were identified from Medline and Scopus databases. Observational studies with NLR as a study factor were eligible for review. The outcomes of interest were any type of CVD including acute coronary syndrome, coronary artery disease, stroke, or a composite of these cardiovascular events. Mean differences in NLR between CVD and non-CVD patients were pooled using unstandardized mean difference (USMD). Odds ratios of CVD between high and low NLR groups were pooled using a random effects model. Results: Thirty-eight studies (n=76,002) were included. High NLR was significantly associated with the risks of CAD, ACS, stroke, and composite cardiovascular events with pooled ORs of 1.62 (95% CI: 1.38-1.91), 1.64 (95% CI: 1.30, 2.05), 2.36 (95% CI: 1.44, 2.89), and 3.86 (95% CI: 1.73, 8.64), respectively. In addition, mean NLRs in CAD, ACS, and stroke patients were significantly higher than in control groups. Conclusion: High NLR was associated with CAD, ACS, stroke, and composite cardiovascular events. Therefore, NLR may be a useful CVD biomarker.
- Subject
- NLR; CVD; cardiovascualr diseases; coranary artery disease; biomarkers
- Identifier
- http://hdl.handle.net/1959.13/1401655
- Identifier
- uon:34942
- Identifier
- ISSN:2314-6133
- Rights
- Copyright © 2018 Teeranan Angkananard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
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